Compensatory renal growth after unilateral ureteral obstruction
نویسندگان
چکیده
منابع مشابه
Compensatory renal growth after unilateral ureteral obstruction.
Compensatory renal growth after unilateral ureteral obstruction. The accumulation of bulk renal protein, RNA and DNA was studied in mice during a 35-day period of accelerated renal growth in the kidney contralateral to that obstructed by acute ureteral ligation. Control mice were sham-operated and nonoperated. RNA was determined by the method of Monroe and Fleck, DNA after Ceriotti and protein ...
متن کاملSimplified Stereological Evaluation of Renal Morphology after Unilateral Ureteral Obstruction
OBJECTIVE AND METHODS This study established a simple stereological method to obtain quantitative information about two- or three-dimensional structures based on observations from kidney sections in the unilateral ureteral obstruction(UUO) model. RESULTS Tubulointerstitial area(TA) and TA/the area of a rectangular field(RA) were raised gradually, but significantly, in the obstructed kidney fr...
متن کاملL-Endoglin Overexpression Increases Renal Fibrosis after Unilateral Ureteral Obstruction
Transforming growth factor-β (TGF-β) plays a pivotal role in renal fibrosis. Endoglin, a 180 KDa membrane glycoprotein, is a TGF-β co-receptor overexpressed in several models of chronic kidney disease, but its function in renal fibrosis remains uncertain. Two membrane isoforms generated by alternative splicing have been described, L-Endoglin (long) and S-Endoglin (short) that differ from each o...
متن کاملSREBP inhibition ameliorates renal injury after unilateral ureteral obstruction.
Tubulointerstitial fibrosis is a major feature associated with declining kidney function in chronic kidney disease of diverse etiology. No effective means as yet exists to prevent the progression of fibrosis. We have shown that the transcription factor sterol-regulatory element-binding protein 1 (SREBP-1) is an important mediator of the profibrotic response to transforming growth factor-β (TGF-...
متن کاملRenin-angiotensin system and unilateral ureteral obstruction
Unilateral ureteral obstruction (UUO) is a clinical scenario that leads to obstructive nephropathy. UUO alters the expression of many mediators in the ipsilateral kidney. Renin-angiotensin system (RAS) is involved in UUO. Angiotensin II (Ang II) and angiotensin 1-7 (Ang 1-7) as the main arms of RAS influence kidney function which may alter by UUO. Ang II via Ang II receptor subtypes I (AT1R) ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Kidney International
سال: 1973
ISSN: 0085-2538
DOI: 10.1038/ki.1973.76